Pox of LeChuck was a voodoo-based curse that affected some of the pirates in the Gulf of Melange.
It was released when Guybrush Threepwood stabbed LeChuck with a faulty Cursed Cutlass of Kaflu which had been made using inferior ingredients. When the cutlass hit LeChuck, it was meant to destroy the demon forever, but instead it sucked out his voodoo essence, sending some into Threepwood's hand and the rest into the air to infect the nearby population.
The effects of the pox caused its victims to become more aggressive and uncontrollable, even lashing out at those close to them. It occured in various stages that seemed to affect some faster than others:
- Skin would turn green and blotchy in areas.
- Random uncontrollable outbursts of anger and hostility would happen at any time, usually when in disagreement with someone.
- Skin would be completely covered in green blotches.
- The rage would take control and the victim would be entirely evil and fearsome.
For an unknown reason, the pox only affected real pirates.
A side effect seemed to be that severed limbs that had been infected would remain alive such as Threepwood's hand.
- Guybrush Threepwood
- Elaine Marley
- Captain McGillicutty
- Hemlock McGee
- Killick Hardtack
- Murkel Trenchfoot
- Bosun Krebbs